During June, with roadside checks set to take place at all times of the day and night - and on all types of road, more than 100,000 drivers are likely to be stopped by officers.
Chief Constable Phil Gormley of the Association of Chief Police Officers said: 'This means that if you drive under the influence of alcohol or drugs, there is a good chance you will be stopped and tested'.
In 2009, of all the people killed on British roads 17 per cent died in an incident involving a drink-driver.
'This tragic and needless waste of human life is totally unacceptable and we will continue to use intelligence to target offenders, as well as carrying out volume testing at the roadside,' said Chief Constable Gormley.
'Our message is clear: Have fun, drink if you want to, but don't then get behind the wheel and drive. If you take that risk, you will be caught.'
A driving ban, prison or a fine of up to £5,000 can be awarded to anyone caught by by police.
In 2010, just under 101,000 drivers were stopped by police and tested during the 30-day summer campaign, with more than 5,000 producing positive results or refusing to be tested.
In the UK, the legal limits for drink-driving are 35 micrograms of alcohol in 100millilitres of breath, 80µg of alcohol per 100 ml of blood, or 107µg of alcohol per 100ml of urine.